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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
27.27
Human Site:
S406
Identified Species:
42.86
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Chimpanzee
Pan troglodytes
XP_509323
803
92478
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Rat
Rattus norvegicus
Q66HD0
804
92752
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
S422
D
E
Y
G
S
K
K
S
D
F
I
K
L
Y
V
Chicken
Gallus gallus
P08110
795
91537
S405
D
E
Y
G
S
K
K
S
D
F
I
K
L
Y
V
Frog
Xenopus laevis
NP_001083114
805
92996
I405
D
E
Y
G
S
K
K
I
D
F
I
K
L
F
V
Zebra Danio
Brachydanio rerio
Q90474
725
83300
P372
D
N
C
E
E
L
I
P
E
Y
L
N
F
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
E365
N
C
E
D
L
I
P
E
Y
L
N
F
M
K
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
P350
E
N
C
E
E
L
M
P
E
Y
L
N
F
I
K
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
F406
F
Q
D
Y
G
K
K
F
D
N
I
K
L
Y
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
L363
I
M
D
N
C
E
E
L
I
P
E
W
L
G
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
K413
E
S
Y
Y
N
S
N
K
A
N
L
K
L
Y
V
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
L353
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
93.3
80
13.3
N.A.
0
N.A.
6.6
53.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
93.3
26.6
N.A.
13.3
N.A.
26.6
60
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
6.6
N.A.
33.3
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
53.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
7
14
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
0
20
7
0
0
7
0
60
0
0
0
0
0
0
% D
% Glu:
14
54
7
20
14
14
7
7
14
0
14
0
0
0
0
% E
% Phe:
7
0
0
0
0
0
0
7
0
20
0
7
14
7
14
% F
% Gly:
0
0
0
54
7
0
0
0
0
0
0
0
0
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
0
0
0
0
7
7
7
14
0
60
0
0
14
0
% I
% Lys:
0
0
0
0
0
60
60
7
0
0
0
67
0
7
14
% K
% Leu:
0
0
0
0
7
14
0
14
0
7
20
0
80
0
0
% L
% Met:
0
7
0
0
0
0
7
0
0
0
0
0
7
0
0
% M
% Asn:
7
14
0
7
7
0
7
0
0
14
7
14
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
14
0
14
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
54
7
0
47
0
0
0
0
0
7
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
14
0
0
0
% W
% Tyr:
0
0
60
14
0
0
0
0
7
47
0
0
0
60
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _